Prof. Jonas Tegenfeldt, PhD

Solid State Physics




74. Ewan Henry, Stefan H. Holm, Zunmin Zhang, Jason P. Beech, Jonas O. Tegenfeldt, Dmitry Fedosov, and Gerhard Gompper, “Sorting cells by their dynamical properties”, Scientific Reports 6, 34375 (2016) Abstract


73. Stefan H. Holm, Jason P. Beech, Michael P. Barrett, Jonas O. Tegenfeldt, “Simplifying Microfluidic Separation Devices towards Field-Detection of Blood Parasites” Analytical Methods 8, 3291-3300 (2016) Abstract Cover



72. Henrik Persson, Zhen Li, Jonas O. Tegenfeldt, Stina Oredsson, and Christelle N. Prinz, “From immobilized cells to motile cells on a bed-of-nails: effects of vertical nanowire array density on cell behaviour”, Scientific Reports 5, 18535 (2015) Abstract


71. V. Iarko, E. Werner, L. K. Nyberg, V. Müller, J. Fritzsche, T. Ambjörnsson, J. P. Beech, J. O. Tegenfeldt, K. Mehlig, F. Westerlund, B. Mehlig, “Extension of nano-confined DNA: quantitative comparison between experiment and theory”, Physical Review E 92(6), 062701 (2015) Abstract


70. M. Reiter-Schad, E. Werner, J. O. Tegenfeldt, B. Mehlig, and Tobias Ambjörnsson, “How nanochannel confinement affects the DNA melting transition within the Poland-Scheraga model”, J Chem Phys, 143 (11), 115101 Abstract


69. C. Freitag, C. Noble, J. Fritzsche, F. Persson, M. Reiter-Schad, A. N. Nilsson, A. Graneli, T. Ambjörnsson, K. U. Mir and Jonas O. Tegenfeldt, “Visualizing the entire DNA from a chromosome in a single frame”, Biomicrofluidics, 9, 044114 (2015) Abstract


68. Charleston Noble, Adam N. Nilsson, Camilla Freitag, Jason P. Beech, Jonas O. Tegenfeldt, Tobias Ambjörnsson, “A fast and scalable kymograph alignment algorithm for nanochannel-based optical DNA mappings”, PLOS One, 10(4): e0121905 (2015) Abstract


67. Mohammadreza Alizadehheidari, Erik Werner, Charleston Noble, Michaela Reiter-Schad, Lena K. Nyberg, Joachim Fritzsche, Bernhard Mehlig, Jonas O. Tegenfeldt, Tobias Ambjörnsson, Fredrik Persson and Fredrik Westerlund, “Nanoconfined circular and linear DNA – equilibrium conformations and unfolding kinetics”, Macromolecules, 48 (3), pp 871–878 (2015) Abstract



66. Cassandra S. Niman, Martin J. Zuckermann, Martina Balaz, Jonas O. Tegenfeldt, Paul M. G. Curmi, Nancy R. Forde, Heiner Linke, "Fluidic Switching in Nanochannels for Control of Inchworm: A Synthetic Biomolecular Motor with a Power Stroke", Nanoscale 6(24), 15008-19 (2014) Abstract

65. Michael Fritzsche, Joachim Fritzsche, Jonas O Tegenfeldt, Carl-Fredrik Mandenius, "A Highly UV-transparent Fused Silica Biochip for Sensitive Hepatotoxicity Testing by Autofluorescence", BioChip Journal 8(2), 115-121 (2014) Abstract

64. Adam N. Nilsson, Gustav Emilsson, Lena Nyberg, Charleston Noble, Liselott Svensson Stadler, Joachim Fritzsche, Edward R. B. Moore, Jonas O. Tegenfeldt, Tobias Ambjörnsson , Fredrik Westerlund, "Competitive binding-based optical DNA mapping for fast identification of bacteria - multi-ligand transfer matrix theory and experimental applications on Escherichia coli", Nucleic Acids Research 42(15), e118 (2014) Abstract



63. Adolfsson, Karl; Persson, Henrik; Wallentin, Jesper; Oredsson, Stina; Samuelson, Lars; Tegenfeldt, Jonas O.; Borgstrom, Magnus; Prinz, Christelle, "Fluorescent nanowire heterostructures as a versatile tool for biology applications.", Nano Letters 13(10), 4728-4732 (2013) Abstract

62. Karolin Frykholm, Camilla Freitag, Fredrik Persson, Jonas O. Tegenfeldt, Annette Granéli " Probing concentration-dependent behavior of DNA-binding proteins on a single molecule level illustrated by Rad51", Analytical biochemistry 443(2), 261-268 (2013) Abstract

61. Erik Werner, Fredrik Westerlund, Jonas O. Tegenfeldt, Bernhard Mehlig "Density profile of DNA, Macromolecules 46(16), 6644–6650 (2013) Abstract

60. Henrik Persson, Carsten Købler, Kristian Mølhave, Lars Samuelson, Jonas O. Tegenfeldt, Stina Oredsson, Christelle Prinz, “Nanowires reduce cell motility and impair cell division”, Small 9(23), 3905–4084 Abstract Cover Materials Views

59. Cassandra S. Niman, Jason P. Beech, Jonas O. Tegenfeldt, Paul M.G. Curmib, Derek N. Woolfsond, Nancy R. Forde, and Heiner Linke, "Controlled microfluidic switching in arbitrary time-sequences with low drag", Lab on a Chip 13(12), 2389-2396 (2013) Abstract



58. Eric Werner, Fredrik Persson, Fredrik Westerlund, Jonas O. Tegenfeldt, Bernhard Mehlig, “Orientational effects on confined DNA”, Physical Review E, 86(4), 041802 (2012) Abstract

57. Gabriel Ohlsson, Seyed R. Tabaei, Jason Beech, Jan Kvassman, Urban Johanson, Per Kjellbom, Jonas O. Tegenfeldt and Fredrik Höök, : “Solute transport on the sub 100 ms scale across the lipid bilayer membrane of individual proteoliposomes” Lab on a Chip, 12, 4635-4643 (2012) Abstract

56. Fredrik Persson, Joachim Fritzsche, Kalim U Mir, Mauro Modesti, Fredrik Westerlund, Jonas O. Tegenfeldt, “Lipid-based passivation in nanofluidics”, Nano Letters, 12 (5), 2260-2265 (2012) Abstract from the cover

55. Jason P. Beech, Stefan Holm, Kalle Adolfsson, Jonas O. Tegenfeldt, “Sorting cells by size, shape and deformability”, Lab on a Chip, 12, 1048-1051 (2012) Abstract Supplementary information Top ten most accessed paper JAN 2012 Lab on a Chip Top 10%

54.  J. Lin, F. Persson, Joachim Fritzsche, J. O. Tegenfeldt, O. A. Saleh, “Bandpass filtering of DNA elastic modes using confinement and tension” Biophysical Journal, 102(1), 96-100 (2012) Abstract

53.  Henrik Persson, Jason P. Beech, Lars Samuelson, Christelle N. Prinz, Jonas O. Tegenfeldt, “Vertical oxide nanotubes connected by subsurface microchannels”, Nano Research 5(3), 190–198 (2012) Abstract

52.  Lena K Nyberg, Fredrik Persson, Johan Berg, Johanna Bergström, Emelie Fransson, Linnea Olsson, Moa Persson, Antti Stålnacke, Jens Wigenius, Jonas O Tegenfeldt, Fredrik Westerlund, “A single-step competitive binding assay for mapping of single DNA molecules” Biochemical and Biophysical Research Communications, 417, 404-408 (2012) Abstract



51. Fredrik Persson, Pit Bingen, Thorsten Staudt, Johann Engelhardt, Jonas O. Tegenfeldt, Stefan W. Hell “Fluorescence nanoscopy of single DNA molecules using STED”, Angewandte Chemie, 50(24), 5581-5583 (2011) Abstract

50.  Stefan Holm*, Jason P. Beech*, Michael P. Barrett, and Jonas O. Tegenfeldt, “Separation of parasites from human blood using deterministic lateral displacement”, Lab Chip, 11, 1326-1332 (2011) Abstract and Supplementary Material Feature in Chemistry World



49.  Al-Fandi, M., M.A.K. Jaradat, K. Fandi, J.P. Beech, J.O. Tegenfeldt, and T.C. Yih, “Nano-engineered living bacterial motors for active microfluidic mixing” IET Nanobiotechnology, 2010. 4(3): p. 61-71.

48. Walter W. Reisner, Niels B. Larsen, Asli Silahtaroglu, Anders Kristensen, Niels Tommerup, Jonas O. Tegenfeldt*, Henrik Flyvbjerg* “Single-Molecule Denaturation Mapping of Genomic DNA in Nanofluidic Channels”, Proceedings of the National Academy of Sciences USA 107 (30), 13294-13299 Abstract Supplementary Material Feature on GenomeWeb Feature in Nature Methods

47. Fredrik Westerlund, Fredrik Persson, Anders Kristensen and Jonas O. Tegenfeldt, "Fluorescence Enhancement Effects on Single DNA Molecules Confined in Si/SiO2 Nanochannels", Lab on a Chip 10 (16), 2049-2051 Abstract

46. Niklas Sköld, Waldemar Hällström, Henrik Persson, Lars Montelius, Martin Kanje, Lars Samuelson, Christelle N. Prinz, Jonas O. Tegenfeldt, "Nanofluidics in hollow nanowires" Nanotechnology 21(15), 155301 Abstract Feature on nanotechweb


45. Peter Jönsson, Jason P. Beech, Jonas O. Tegenfeldt, and Fredrik Höök, “The Mechanical Behavior of a Supported Lipid Bilayer under External Shear Forces”, Langmuir, 25 (11), 6279-6286 Abstract

44. Jason P. Beech, Peter Jönsson, and Jonas O. Tegenfeldt, “Tipping the balance with dielectrophoresis – electrical deterministic lateral displacement”, Lab Chip, 9, 2698 - 2706 Abstract

43.  Peter Jönsson, Jason P. Beech, Jonas O. Tegenfeldt, and Fredrik Höök, “Shear-Driven Motion of Supported Lipid Bilayers in Microfluidic Channels”, Journal of the American Chemical Society, 131 (14), 5294-5297 (2009) Abstract

42. Walter W. Reisner, Niels B. Larsen, Henrik Flyvbjerg, Jonas O. Tegenfeldt, and Anders Kristensen, “Directed Self-Assembly and Conformational Control of Single DNA Molecules in a Nanoslit via Embedded Nanopit Arrays”, Proceedings of the National Academy of Sciences, USA, 106 (1): 79-84 (2009) Abstract

41. Fredrik Persson, Fredrik Westerlund, Jonas O. Tegenfeldt, Anders Kristensen, “Local Conformation of Confined DNA Studied Using Emission Polarization Anisotropy”, Small, 5(2), 190-193 (2009) Abstract


40. Brian R. Long, Martin Heller, Jason P. Beech, Heiner Linke, Henrik Bruus, Jonas O. Tegenfeldt, “Diffusion and novel sorting modes in deterministic lateral displacement”, Physical Review E, 78(4), 046304 (2008) Abstract

39.  Peter Jönsson, Magnus P. Jonsson, Jonas O. Tegenfeldt, and Fredrik Höök, “A method improving the accuracy of fluorescence recovery after photobleaching analysis”, The Biophysical Journal, 95, 5334-5348 (2008) Abstract

38.  Georgette B. Salieb-Beugelaar, Juliane Teapal, Jan van Nieuwkasteele, Daniël Wijnperlé, Jonas O. Tegenfeldt, Fred Lisdat, Albert van den Berg, and Jan C. T. Eijkel, “Field Dependent DNA Mobility in 20nm High Nanoslits”, 8(7), 1785-1790, Nano Letters (2008) Abstract Highlight

37.  Jason P. Beech & Jonas O. Tegenfeldt, “Tuneable separation in elastomeric microfluidics devices”; Lab on a Chip, 8(5), 657-659 (2008) Abstract Cover Featured in Chemical Technology

36.  Anders Gunnarsson, Peter Jönsson, Rodolphe Marie, Jonas O. Tegenfeldt, Fredrik Höök, ”Single-molecule Detection and Mismatch Discrimination of Unlabeled DNA Targets”, Nano Letters, 8(1), 183-188 (2008) Abstract

35.  Patrick Carlberg, Lars Montelius, and J. Tegenfeldt, “Nanoimprint in PDMS on glass with two-level hybrid stamp”, Microelectronic engineering, 85(1), 210-213 (2008) Abstract



34.  Walter W. Reisner, Jason P. Beech, Niels B. Larsen, Henrik Flyvbjerg, Anders Kristensen, and Jonas O. Tegenfeldt, “Nanoconfinement-enhanced conformational response of single DNA molecules to changes in ionic environment”, Physical Review Letters, 99, 058302  (2007) Abstract

33. Rodolphe Marie, Andreas B. Dahlin, Jonas O. Tegenfeldt, and Fredrik Höök, “A generic surface modification strategy for sensing applications based on Au/SiO2 nanostructures”, Biointerphases, 2(1), 49-54 (2007) Abstract



32. R. Metzler, W. Reisner, R. Riehn, R. Austin, J. O. Tegenfeldt and I. M. Sokolov, “Diffusion mechanisms of localised knots along a polymer”, Europhys. Lett., 76 (4), pp. 696-702 (2006) Abstract

31. Marie, R., Beech, J. P., Vöros, J., Tegenfeldt, J. O., Höök, F. “Use of PLL-g-PEG in Micro-Fluidic Devices for Localizing Selective and Specific Protein Binding”, Langmuir; 22(24);  10103-10108 (2006). Abstract

30.  Brian Bilenberg, Søren Jacobsen, M. S. Schmidth, L. H. D. Skjolding, P. Shi, Peter Bøggild, Jonas O. Tegenfeldt, Anders Kristensen, “High resolution 100kV electron beam lithography in SU-8”, Microelectronic Engineering, 83, 1609-1612 (2006) Abstract.

29.  Andreas B. Dahlin, Jonas O. Tegenfeldt and Fredrik Höök, “Improving the Instrumental Resolution of Sensors based on Localized Surface Plasmon Resonance” Analytical Chemistry, 78(13);  4416-4423 (2006). Abstract.



28.  Yan Mei Wang, Jonas O. Tegenfeldt, James Sturm, Robert H. Austin, “Long-range interactions between transcription factors”, Nanotechnology, 16, 1993-1999 (2005) Abstract.

27.  Alf Månsson, Mark Sundberg, Richard Bunk, Martina Balaz, Ian A Nicholls, Pär Omling, Jonas O. Tegenfeldt, Sven Tågerud and Lars Montelius, “Actin-based molecular motors for cargo transportation in nanotechnology – potentials and challenges”, IEEE Transactions on Advanced Packaging, 28(4), 547-555 (2005) Abstract.

26.  B. Bilenberg, M. Hansen, D. Johansen, V. Özkapici, C. Jeppesen, P. Szabo, I. M. Obieta, O. Arroyo, J. O. Tegenfeldt and A. Kristensen, “Topas Based Lab-on-a-chip Microsystems Fabricated by Thermal Nanoimprint Lithography”, Journal of Vacuum Science and Technology B 23(6), 2944-2949 (2005) Abstract.

25.  Pei-Kuen Wei, Hsieh-Li Chou, You-Ren Cheng, Cheng-Hung Wei, Wunshain Fann, and Jonas O. Tegenfeldt, “Beaming Effect of Optical Near-Field in Multiple Metallic Slits with Nanometric Linewidth and Micrometer Pitch”, Optics Communications, 253(1-3), 198-204 (2005) Abstract.

24.  Yan Mei Wang, Jonas O. Tegenfeldt, W. Reisner, R. Riehn, Xiao-Juan Guan, Ido Golding, Edward C. Cox, James Sturm, Robert H. Austin, “Single-molecule studies of repressor-DNA interactions show long-range interactions”, The Proceedings of the National Academy of Sciences, US, 102(28), 9796-9801 (2005) Abstract.



23.  Jonas O. Tegenfeldt, Christelle Prinz, Han Cao, Stephen Y. Chou, Walter W. Reisner, Robert Riehn, Yan Mei Wang, Edward C. Cox, James C. Sturm, Pascal Silberzan, Robert H. Austin, "The dynamics of genomic-length DNA molecules in 100-nm channels", The Proceedings of the National Academy of Sciences, US, 101(30), 10979-10983 (2004) Abstract.

22.  C. H. Wei, P. H. Tsao, and W. S. Fann, P. K. Wei, J. O. Tegenfeldt, R. H. Austin, "Polarization dependence of light intensity distribution near a nanometric aluminum slit", Journal of the Optical Society of America – B, 21(5), 1005-1012 (2004) Abstract.



21.  T. G. I. Ling, M. Beck, R. Bunk. E. Forsén, J. O. Tegenfeldt, A. A. Zakharov, L. Montelius, “Fabrication and characterization of a molecular adhesive layer for micro- and nanofabricated electrochemical electrodes”, Microelectronic Engineering, 67-68, 887-892 (2003) Abstract.

20.  Wanli Li, Jonas O. Tegenfeldt, Lei Chen, Robert H. Austin, Stephen Y. Chou, Paul A. Kohl, Jeff Krotine, and James C. Sturm, “Sacrifical polymers for nanofluidic channels in biological applications”, Nanotechnology 14, 578-583 (2003) Abstract Featured in Science



19.  L. Richard Huang, Jonas O. Tegenfeldt, Jessica Kraeft, James C. Sturm, Robert H. Austin, Edward C. Cox, “A DNA prism for high-speed continuous fractionation of large DNA molecules”, Nature Biotechnology 20(10), 1048-1051 (2002) Abstract Featured in The Economist

18.  Han Cao, Jonas O. Tegenfeldt, Robert H. Austin, Stephen Y. Chou, “Gradient Structures Interfacing Microfluidics and Nanofluidics”, Applied Physics Letters 81(16), 3058-3060 (2002) Abstract Featured in Nature Featured in Nanotechweb

17.  Lotien Richard Huang, Pascal Silberzan, Jonas O. Tegenfeldt, Edward C. Cox, James C. Sturm, Robert H. Austin, and Harold Craighead, “Role of molecular size in ratchet fractionation”, Physical Review Letters, 89(17), 178301 (2002) Abstract.

16.  Christelle Prinz, Jonas O. Tegenfeldt, Robert H. Austin, Edward C. Cox, James C. Sturm, “Bacterial chromosome extraction and isolation”, Lab on a Chip, 2, 207-212 (2002) Abstract.

15.  C-F Chou, J. O. Tegenfeldt, O. Bakajin, S. Chan, E. C. Cox, N. Darnton, T. Duke, R. H. Austin, “Electrodeless Dielectrophoresis of Single- and Double-stranded DNA”, The Biophysical Journal, 83(4), 2170-9 (2002) Abstract.

14.  Robert H. Austin, Jonas O. Tegenfeldt, Han Cao, Stephen Y. Chou, Edward C. Cox, “Scanning the Controls: Genomics and Nanotechnology”, IEEE Transactions on Nanotechnology, 1(1), 12-18 (2002) Abstract.

13.  Han Cao, Zhaoning Yu, Jian Wang, Jonas O. Tegenfeldt, Robert H. Austin, Erli Chen, Wei Wu, Stephen Y. Chou, “Fabrication of 10nm enclosed nanofluidic structures”, Applied Physics Letters, 81(1), 174-176 (2002) Abstract Featured in Nature Featured in SmallTimes



12.  J. O. Tegenfeldt, O. Bakajin, C. F. Chou, S. Chan, R. H. Austin, W. Fann, L. Liou, E. Chan, T. Duke, E. C. Cox, ”Near-Field Scanner for Moving Molecules”, Physical Review Letters, 86(7), 1378-81 (2001) Abstract Featured in Physics Today Featured in Physics Today

11.  N. Darnton, O. Bakajin, R. Huang, B. North, J. O. Tegenfeldt, E. C. Cox, J. Sturm, and R. H. Austin, “Hydrodynamics in 2 1/2 dimensions: making jets in a plane”, Journal of Physics: Condensed Matter, 13(21), 4891-4902 (2001) Abstract.

10.  Olgica Bakajin, Thomas A. J. Duke, Jonas Tegenfeldt, Chia-Fu Chou, Shirley S. Chan, Robert H. Austin, and Edward C. Cox; Separation of 100-Kilobase DNA Molecules in 10 Seconds, Analytical Chemistry; 73(24); 6053-6056 (2001) Abstract.

9.    L.R. Huang, J.O. Tegenfeldt, J.J. Kraeft, J.C. Sturm, R.H. Austin, E.C.Cox, "Generation of large-area tunable uniform electric fields in microfluid arrays for rapid DNA separation", Technical Digest International Electron Devices Meeting (Washington DC), pp. 363-366 (2001) Abstract.



8.    C.-F. Chou, R. H. Austin, O. Bakajin, J. O. Tegenfeldt, J. A. Castelino, S. S. Chan, E. C. Cox, H. Craighed, N. Darnton, T. A. J. Duke, J. Han, S. Turner, “Sorting Biomolecules with Microdevices”, Electrophoresis, 21 (1), 81-90 (2000) Abstract.



7.    F. Lundberg, D.-Q. Li, D. Falkenback, T. Lea, P. Siesjö, S. Söderström, B. J. Kudryk, J. O. Tegenfeldt, S. Nomura, Å. Ljungh, “Presence of vitronectin and activated complement factor C9 on ventriculoperitoneal shunts and temporary ventricular drainage catheters”, Journal of Neurosurgery, 90 (1), 101-8 (Jan, 1999) Abstract.



6.    M. Stollenwerk, C. Fallgren, F. Lundberg, J. O. Tegenfeldt, L. Montelius, Å. Ljungh, "Quantitation of bacterial adhesion on polymer surfaces by bioluminescence", Zentralblatt fur Bakteriologie 287(1-2), 7-18 (1998)



5.    F. Lundberg, J. O. Tegenfeldt, L. Montelius, U. Ransjö, P. Appelgren, P. Siesjö and Å. Ljungh, "Protein depositions on one hydrocephalus shunt and on fifteen temporary ventricular  catheters", Acta Neurochirurgica 139 (8), 734-742 (1997) Abstract.



4.    L. Montelius, J. O. Tegenfeldt, and T. G. I. Ling, “Fabrication and characterization of a nanosensor for admittance spectroscopy of biomolecules”, J Vac Sci Technol A 13 (3), 1755-1760 (1995). Abstract.

3.    J. O. Tegenfeldt and L. Montelius, “Image widening not only a question of tip sample convolution”, Applied Physics Letters 66 (9), 1068-1070 (1995). Abstract.



2.    L. Montelius, J.O. Tegenfeldt, and P. van Heeren, “Direct Observation of the Atomic Force Microscopy Tip Using Inverse Atomic Force Microscopy Imaging,” J Vac Sci Technol B 12 (3), 2222-2226 (1994). Abstract.



1.    L. Montelius and J. O. Tegenfeldt, “Direct observation of the tip shape in scanning probe microscopy”, Applied Physics Letters 62 (21), 2628-2630 (1993). Abstract.



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Contact information Lund:


Jonas Tegenfeldt

Office Q142
Division of Solid State Physics
Department of Physics
Lund University
Box 118
SE-221 00 Lund

Visiting address:
Professorsgatan 1
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Office Phone: +46-(0)46-222 8063 (forwarded to mobile phone)
Fax: +46-(0)46-222 3637
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Optics and fluidics labs (Q129 and Q112)
Soft lithography (PDMS) lab (Q126)
Super resolution microscopy (STED) lab (Q115)

Short CV:

2014 - present Full Professor at Solid State Physics, Lund University

2008-2014 VR-financed "Rådsforskare" (Eng: Senior Research Fellowship Award)

2003-2008 VR-financed "Forskarassistent" (Eng: Assistant Professor)

2007 Docent (Associate Professor) in Solid State Physics

1998 - 2003 PostDoc at Princeton University

1997 PhD in Solid State Physics Lund University

1991 MSc in Engineering Physics / Materials Science Uppsala University

1986 Swedish Defense Institute of Language (Military Service)

Research interests

Micro and nanotechnology to address life science problems.


  • Separation science
  • Nanofluidics
  • Polymers in confined environments
  • Tools for single-cell biology
  • Super resolution microscopy (STED)